* Acquisition of CD30 and CD15 accompanied with simultaneous loss of all pan-T-cell antigens in a case of histological transformation of mycosis fungoides with involvement of regional lymph node: an immunophenotypic alteration resembling classical Hodgkin lymphoma.
- : Acquired expression of CD30 is frequently noted in histological transformation of mycosis fungoides (MF), but simultaneous gain of CD15 accompanied with loss of pan-T-cell antigens are extremely rare. We report an unusual case of transformed MF with such an immunophenotypic alteration resembling classical Hodgkin lymphoma. The patient was an 81-year-old male with MF, who was initially treated with topical steroids and phototherapy. Despite the initial response, the patient developed a tumor-like skin lesion that was confirmed to be CD30-positive large T-cell lymphoma and was subsequently found to have a regional lymph node involvement by pleomorphic large cell lymphoma. Besides CD30, pleomorphic large cells were positive for CD15 but negative for all B cell- and T cell-specific antigens. Epstein-Barr virus was negative. Polymerase chain reaction-based assays demonstrated a clonal rearrangement of T-cell receptor gamma gene but detected no B-cell clone. The mechanism and clinical significance of this phenotypic conversion remains to be elucidated.
=>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした
Overview of noun specific
The noun specific has 2 senses (no senses from tagged texts)
1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from
the particular to the general")
2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a
specific for malaria")
Overview of adj specific
The adj specific has 4 senses (first 2 from tagged texts)
1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing
something particular or special or unique; "rules with specific application"; "demands specific to
the job"; "a specific and detailed account of the accident")
2. (5) specific -- (stated explicitly or in detail; "needed a specific amount")
3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific
characters")
4. specific -- (being or affecting a disease produced by a particular microorganism or condition;
used also of stains or dyes used in making microscope slides; "quinine is highly specific for
malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular
structural elements")
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