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return kwic search for specific out of >500 occurrences
279736 occurrences (No.90 in the rank) during 5 years in the PubMed. [no cache] 500 found
68) Here we used specific antibodies against N-acetylaspartate and immunocytochemistry of carbodiimide-fixed adult rodent brain to show that, besides staining of neuronal cell bodies in the grey matter, N-acetylaspartate labelling was present in oligodendrocytes/myelin in white matter tracts.
--- ABSTRACT ---
PMID:24379086 DOI:10.1007/s00429-013-0691-7
2015 Brain structure & function
* Localisation of N-acetylaspartate in oligodendrocytes/myelin.
- The role of N-acetylaspartate in the brain is unclear. Here we used specific antibodies against N-acetylaspartate and immunocytochemistry of carbodiimide-fixed adult rodent brain to show that, besides staining of neuronal cell bodies in the grey matter, N-acetylaspartate labelling was present in oligodendrocytes/myelin in white matter tracts. Immunoelectron microscopy of the rat hippocampus showed that N-acetylaspartate was concentrated in the myelin. Also neuronal cell bodies and axons contained significant amounts of N-acetylaspartate, while synaptic elements and astrocytes were low in N-acetylaspartate. Mitochondria in axons and neuronal cell bodies contained higher levels of N-acetylaspartate compared to the cytosol, compatible with synthesis of N-acetylaspartate in mitochondria. In aspartoacylase knockout mice, in which catabolism of N-acetylaspartate is blocked, the levels of N-acetylaspartate were largely increased in oligodendrocytes/myelin. In these mice, the highest myelin concentration of N-acetylaspartate was found in the cerebellum, a region showing overt dysmyelination. In organotypic cortical slice cultures there was no evidence for N-acetylaspartate-induced myelin toxicity, supporting the notion that myelin damage is induced by the lack of N-acetylaspartate for lipid production. Our findings also implicate that N-acetylaspartate signals on magnetic resonance spectroscopy reflect not only vital neurons but also vital oligodendrocytes/myelin.
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(1)15 to (19)4 types (37)2 attention (55)2 lineages
(2)9 sequence (20)3 characteristics (38)2 barriers (56)2 measures
(3)7 and (21)3 features (39)2 computational (57)2 miRNAs
(4)7 cell (22)3 job (40)2 constitutive (58)2 molecular
(5)7 variations (23)3 target (41)2 criteria (59)2 neuronal
(6)6 cognitive (24)3 tendon (42)2 deficits (60)2 or
(7)6 genes (25)3 therapy (43)2 differences (61)2 parameters
(8)6 surface (26)3 type (44)2 divergence (62)2 phytotoxicity
(9)5 antibodies (27)3 variation (45)2 effect (63)2 polymerase
(10)5 for (28)2 *null* (46)2 elements (64)2 primers
(11)5 phobias (29)2 ECM (47)2 ethnocultural (65)2 protein
(12)4 brain (30)2 IgG (48)2 extracellular (66)2 proteins
(13)4 effects (31)2 PCR (49)2 fault (67)2 recommendations
(14)4 growth (32)2 age-dependent (50)2 function (68)2 requirements
(15)4 incidence (33)2 analysis (51)2 genetic (69)2 self-efficacy
(16)4 manner (34)2 antigen (52)2 genomic (70)2 targeted
(17)4 motor (35)2 antigens (53)2 information (71)2 tests
(18)4 needs (36)2 approach (54)2 inhibitors

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--- WordNet output for specific --- =>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした Overview of noun specific The noun specific has 2 senses (no senses from tagged texts) 1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from the particular to the general") 2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria") Overview of adj specific The adj specific has 4 senses (first 2 from tagged texts) 1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing something particular or special or unique; "rules with specific application"; "demands specific to the job"; "a specific and detailed account of the accident") 2. (5) specific -- (stated explicitly or in detail; "needed a specific amount") 3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific characters") 4. specific -- (being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements") --- WordNet end ---