ELIZA

return kwic search for system out of >500 occurrences
331253 occurrences (No.58 in the rank) during 5 years in the PubMed. [cache]

271) The melanocortins, and in particular α- and γ-MSH, have been shown to exert their cardiovascular activity both at the central nervous system level and in the periphery (e.g., in the adrenal gland), binding their receptors MC3R and MC4R and influencing the activity of the sympathetic nervous system.

--- ABSTRACT ---

PMID:34512392 DOI:10.3389/fphys.2021.725709

2021 Frontiers in physiology

* Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions.

- Increasing evidence indicates that the melanocortin system is not only a central player in energy homeostasis, food intake and glucose level regulation, but also in the modulation of cardiovascular functions, such as blood pressure and heart rate. The melanocortins, and in particular α- and γ-MSH, have been shown to exert their cardiovascular activity both at the central nervous system level and in the periphery (e.g., in the adrenal gland), binding their receptors MC3R and MC4R and influencing the activity of the sympathetic nervous system. In addition, some studies have shown that the activation of MC3R and MC4R by their endogenous ligands is able to improve the outcome of cardiovascular diseases, such as myocardial and cerebral ischemia. In this brief review, we will discuss the current knowledge of how the melanocortin system influences essential cardiovascular functions, such as blood pressure and heart rate, and its protective role in ischemic events, with a particular focus on the central regulation of such mechanisms.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to system]

(1)71 null	(13)6 the	(25)3 incorporating	(37)2 being
(2)44 and	(14)6 which	(26)3 level	(38)2 but
(3)17 is	(15)5 has	(27)3 may	(39)2 devices
(4)17 to	(16)4 by	(28)3 using	(40)2 especially
(5)12 for	(17)4 should	(29)3 we	(41)2 genes
(6)12 in	(18)4 were	(30)2 (CNS),	(42)2 identified
(7)12 of	(19)4 with	(31)2 (ECS)	(43)2 including
(8)7 are	(20)3 as	(32)2 (GIS)	(44)2 it
(9)7 that	(21)3 barriers	(33)2 (SNS)	(45)2 levels
(10)7 was	(22)3 can	(34)2 Online	(46)2 remains
(11)6 (CNS)	(23)3 could	(35)2 acts	(47)2 seems
(12)6 group	(24)3 factors	(36)2 becomes	(48)2 throughout

add keyword

--- WordNet output for system --- =>制度組織体系的方式, システム, 組織, 整然とした手順, (思想などの)体系, 体制 Overview of noun system The noun system has 9 senses (first 8 from tagged texts) 1. (43) system -- (instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer") 2. (23) system, scheme -- (a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going") 3. (14) system -- ((physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide") 4. (10) system, system of rules -- (a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender") 5. (8) arrangement, organization, organisation, system -- (an organized structure for arranging or classifying; "he changed the arrangement of the topics"; "the facts were familiar but it was in the organization of them that he was original"; "he tried to understand their system of classification") 6. (7) system -- (a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion") 7. (6) system -- (a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation") 8. (1) system -- (the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system") 9. organization, organisation, system -- (an ordered manner; orderliness by virtue of being methodical and well organized; "his compulsive organization was not an endearing quality"; "we can't do it unless we establish some system around here") --- WordNet end ---