ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for system out of >500 occurrences
331253 occurrences (No.58 in the rank) during 5 years in the PubMed. [cache]
355) The endocannabinoid system (ECS) plays an important role in reparative mechanisms and inflammation under pathological situations by controlling some mechanisms that are shared with minocycline pathways.
* CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.
- Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impairment. Since glial activation plays a key role in the development of this damage, it seems that controlling it could be beneficial and could lead to neuroprotective effects. Recent studies show that minocycline suppresses microglial activation, reduces the lesion volume, and decreases TBI-induced locomotor hyperactivity up to 3 months. The endocannabinoid system (ECS) plays an important role in reparative mechanisms and inflammation under pathological situations by controlling some mechanisms that are shared with minocycline pathways. We hypothesized that the ECS could be involved in the neuroprotective effects of minocycline. To address this hypothesis, we used a murine TBI model in combination with selective CB1 and CB2 receptor antagonists (AM251 and AM630, respectively). The results provided the first evidence for the involvement of ECS in the neuroprotective action of minocycline on brain edema, neurological impairment, diffuse axonal injury, and microglial activation, since all these effects were prevented by the CB1 and CB2 receptor antagonists.
=>制度組織体系的方式, システム, 組織, 整然とした手順, (思想などの)体系, 体制
Overview of noun system
The noun system has 9 senses (first 8 from tagged texts)
1. (43) system -- (instrumentality that combines interrelated interacting artifacts designed to work
as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small
computer")
2. (23) system, scheme -- (a group of independent but interrelated elements comprising a unified
whole; "a vast system of production and distribution and consumption keep the country going")
3. (14) system -- ((physical chemistry) a sample of matter in which substances in different phases
are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system
generating hydrogen peroxide")
4. (10) system, system of rules -- (a complex of methods or rules governing behavior; "they have to
operate under a system they oppose"; "that language has a complex system for indicating gender")
5. (8) arrangement, organization, organisation, system -- (an organized structure for arranging or
classifying; "he changed the arrangement of the topics"; "the facts were familiar but it was in the
organization of them that he was original"; "he tried to understand their system of classification")
6. (7) system -- (a group of physiologically or anatomically related organs or parts; "the body has
a system of organs for digestion")
7. (6) system -- (a procedure or process for obtaining an objective; "they had to devise a system
that did not depend on cooperation")
8. (1) system -- (the living body considered as made up of interdependent components forming a
unified whole; "exercise helped him get the alcohol out of his system")
9. organization, organisation, system -- (an ordered manner; orderliness by virtue of being
methodical and well organized; "his compulsive organization was not an endearing quality"; "we can't
do it unless we establish some system around here")
--- WordNet end ---