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271290 occurrences (No.96 in the rank) during 5 years in the PubMed. [cache]

476) With the development of pharmacological and genetic tools that allow the investigation of microglia in vivo, there have been considerable advances in understanding molecular signatures of both homeostatic microglia and those reacting to injury and disease.

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PMID:33835613 DOI:10.1111/ejn.15225

2021 The European journal of neuroscience

* An overview of microglia ontogeny and maturation in the homeostatic and pathological brain.

- Microglia are the resident immune cells of the central nervous system (CNS) and are increasingly recognized as critical players in development, brain homeostasis, and disease pathogenesis. The lifespan, maintenance, proliferation, and turnover of microglia are important factors that regulate microglial behavior and affect their roles in the CNS. However, emerging evidence suggests that microglia are morphologically and phenotypically distinct in different brain areas, at different ages, and during disease. Ongoing research focuses on understanding how microglia acquire specific phenotypes in response to extrinsic cues in the environment and how phenotypes are specified by intrinsic properties of different populations of microglia. With the development of pharmacological and genetic tools that allow the investigation of microglia in vivo, there have been considerable advances in understanding molecular signatures of both homeostatic microglia and those reacting to injury and disease. Here, we review the master gene regulators that define microglia as well as discuss the evidence that microglia are heterogeneous and fall into distinct clusters that display specific intrinsic properties and perform unique tasks in different settings. Taken together, the information presented supports the idea that microglia morphology and transcriptional heterogeneity should be considered when studying the complex nature of microglia and their roles in brain health and disease.

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(1)242 is	(3)68 was	(5)26 has	(7)5 remains
(2)84 are	(4)49 were	(6)9 have	(8)3 appears

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--- WordNet output for there --- =>1.その場所で, そこに(で), そこへ, 2.〜がある, その場所で Overview of noun there The noun there has 1 sense (no senses from tagged texts) 1. there -- (a location other than here; that place; "you can take it from there") Overview of adv there The adv there has 3 senses (first 3 from tagged texts) 1. (181) there, at that place, in that location -- (in or at that place; "they have lived there for years"; "it's not there"; "that man there") 2. (6) there, in that respect, on that point -- (in that matter; "I agree with you there") 3. (2) there, thither -- (to or toward that place; away from the speaker; "go there around noon!") --- WordNet end ---