ELIZA

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303636 occurrences (No.74 in the rank) during 5 years in the PubMed. [cache]

374) During the screening phase, the factors were evaluated in order to identify those which exert a significant effect.

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PMID:24237328 DOI:10.3109/03639045.2013.858737

2015 Drug development and industrial pharmacy

* Spray drying formulation of albendazole microspheres by experimental design. In vitro-in vivo studies.

- Both an experimental design and optimization techniques were carried out for the development of chitosan-pectin-carboxymethylcellulose microspheres to improve the oral absorption of albendazole as a model drug. The effect of three different factors (chitosan, pectin and carboxy methyl cellulose concentrations) was studied on five responses: yield, morphology, dissolution rate at 30 and 60 min, and encapsulation efficiency of the microspheres. During the screening phase, the factors were evaluated in order to identify those which exert a significant effect. Simultaneous multiple response optimizations were then used to find out experimental conditions where the system shows the most adequate results. The optimal conditions were found to be: chitosan concentration, 1.00% w/v, pectin concentration 0.10% w/v and carboxymethylcellulose concentration 0.20% w/v. The bioavailability of the loaded drug in the optimized microspheres was evaluated in Wistar rats which showed an area under curve (AUC) almost 10 times higher than the pure drug.

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