ELIZA

return kwic search for through out of >500 occurrences
437431 occurrences (No.38 in the rank) during 5 years in the PubMed. [cache]

286) A critical appraisal was performed through ToxRTool, followed by data extraction and qualitative synthesis of outcomes and methodological issues.

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PMID:33831473 DOI:10.1016/j.tiv.2021.105160

2021 Toxicology in vitro : an international journal published in association with BIBRA

* Standardized pyrogen testing of medical products with the bacterial endotoxin test (BET) as a substitute for rabbit Pyrogen testing (RPT): A scoping review.

- The Bacterial Endotoxin Test (BET) is a method for exclusion of endotoxin-related pyrogen contamination in pharmaceutical products, as an alternative to the Rabbit Pyrogen Test (RPT). However, BET does not detect a broad range of biologically relevant pyrogens, and interferences can limit its practical use for different medical products. This work aimed to scope the evidence in the scientific literature for case-by-case validity assessments of BET in different uses for medical products. A search strategy was conducted in PubMed, Scopus, and Web of Science in April 2020, according to the PRISMA-ScR statement. Twenty-two references were included, evaluating medical products for endotoxin contamination through both BET and RPT according to standardized protocols. A critical appraisal was performed through ToxRTool, followed by data extraction and qualitative synthesis of outcomes and methodological issues. Four classes of products assessed by BET were identified, including nanoparticles, drugs, blood and biological products. A considerable variation was observed on the BET methods used. Collectively, the evidence indicates different factors influencing the outcome of BET, including the chemical nature of samples that may cause interference depending on the selected method. While some applications to medical products appear adequate, others, such as nanoparticles, may require the use of different in vitro pyrogen testing methods, reinforcing the need for case-by-case validation for each BET method and type of medical product.

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[frequency of next (right) word to through]

(1)82 the	(13)3 discussion	(25)2 Google	(37)2 improving
(2)42 a	(14)3 food	(26)2 MEDLINE,	(38)2 induction
(3)8 an	(15)3 information	(27)2 Medline,	(39)2 lipid
(4)8 this	(16)3 inhibition	(28)2 PubMed	(40)2 multiple
(5)7 which	(17)3 its	(29)2 PubMed,	(41)2 nutrition
(6)6 resolution	(18)3 modulation	(30)2 abutment	(42)2 providing
(7)4 October	(19)3 searches	(31)2 analysis	(43)2 reference
(8)4 different	(20)3 several	(32)2 assessment	(44)2 semi-structured
(9)4 various	(21)3 their	(33)2 binding	(45)2 simulation
(10)3 January	(22)3 these	(34)2 dual	(46)2 specific
(11)3 July	(23)2 April	(35)2 gap	(47)2 thematic
(12)3 both	(24)2 August	(36)2 genetic

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--- WordNet output for through --- =>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて Overview of adj through The adj through has 2 senses (first 1 from tagged texts) 1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make history before he's done"; "it's a done deed"; "after the treatment, the patient is through except for follow-up"; "almost through with his studies") 2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a through street"; "a through bus"; "through traffic") Overview of adv through The adv through has 5 senses (first 3 from tagged texts) 1. (5) through -- (from beginning to end; "read this book through") 2. (2) through -- (over the whole distance; "this bus goes through to New York") 3. (1) through -- (to completion; "think this through very carefully!") 4. through -- (in diameter; "this cylinder measures 15 inches through") 5. through, through and through -- (throughout the entire extent; "got soaked through in the rain"; "I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and through"; "boards rotten through and through") --- WordNet end ---