* Massive intravascular hemolysis from Clostridium perfringens septicemia: a review.
- We describe the case of a patient with hemolysis-associated Clostridium perfringens septicemia and review all similar cases published in the literature since 1990, with specific focus on the relationship between treatment strategy and survival. We searched PubMed for all published cases of C. perfringens-associated hemolysis, using the medical subject terms "clostridia," "clostridial sepsis," and/or "hemolysis." All case reports, case series, review articles, and other relevant references published in the English literature since 1990 were included in this study. There were no exclusion criteria. Each case was examined with respect to presenting features of illness, antibiotic regimen, time-to-antibiotic therapy, additional interventions, complications, and patient survival. These variables were entered into a data set and then systematically analyzed with the aid of a statistician, using serial t tests and chi-square analyses. Since 1990, 50 patients of C. perfringens septicemia with hemolysis have been reported. Median age was 61 years (range 31-84), and 58% were male. Mortality was 74%, with a median time to death of 9.7 hours (range 0-96 hours). Of the patients, 35 (70%) were treated medically, while 15 (30%) received antibiotics and surgery. Surgical intervention was associated with significantly improved survival (risk ratio [RR] 0.23, 95% confidence interval [CI] 0.10, 0.53) as was the use of a combination of penicillin and clindamycin (RR of death 0.46, 95% CI 0.25, 0.83). Four patients utilizing hyperbaric oxygen therapy (HBOT) have been reported, and all patients survived. In cases of clostridial sepsis with hemolysis, strong predictors of survival include early initiation of appropriate antibiotics as well as surgical removal of infected foci. The HBOT may also be associated with survival. The disease often progresses rapidly to death, so rapid recognition is critical for the patient survival.
=>1.時代, 季節, 歳月, 当時, 現代, 一生, 年季, 就業時間, 期間, 時刻, 時点, 機会, 拍子, 速度, 何度, 何回,
時, 時間, 回, 2.時間[速度]を測定する, 時間を決める, (装置などの)タイミングを調節する
Overview of noun time
The noun time has 10 senses (first 9 from tagged texts)
1. (219) time, clip -- (an instance or single occasion for some event; "this time he succeeded"; "he
called four times"; "he could do ten at a clip")
2. (160) time -- (a period of time considered as a resource under your control and sufficient to
accomplish something; "take time to smell the roses"; "I didn't have time to finish"; "it took more
than half my time")
3. (114) time -- (an indefinite period (usually marked by specific attributes or activities); "he
waited a long time"; "the time of year for planting"; "he was a great actor in his time")
4. (43) time -- (a suitable moment; "it is time to go")
5. (36) time -- (the continuum of experience in which events pass from the future through the
present to the past)
6. (10) time -- (a person's experience on a particular occasion; "he had a time holding back the
tears"; "they had a good time together")
7. (7) clock time, time -- (a reading of a point in time as given by a clock; "do you know what time
it is?"; "the time is 10 o'clock")
8. (5) fourth dimension, time -- (the fourth coordinate that is required (along with three spatial
dimensions) to specify a physical event)
9. (1) meter, metre, time -- (rhythm as given by division into parts of equal duration)
10. prison term, sentence, time -- (the period of time a prisoner is imprisoned; "he served a prison
term of 15 months"; "his sentence was 5 to 10 years"; "he is doing time in the county jail")
Overview of verb time
The verb time has 5 senses (first 3 from tagged texts)
1. (4) clock, time -- (measure the time or duration of an event or action or the person who performs
an action in a certain period of time; "he clocked the runners")
2. (3) time -- (assign a time for an activity or event; "The candidate carefully timed his
appearance at the disaster scene")
3. (1) time -- (set the speed, duration, or execution of; "we time the process to manufacture our
cars very precisely")
4. time -- (regulate or set the time of; "time the clock")
5. time -- (adjust so that a force is applied and an action occurs at the desired time; "The good
player times his swing so as to hit the ball squarely")
--- WordNet end ---