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211) A total number of 104 fish were injected by 10, 50, 100, 150 and 200 µg g(-) (1) week(-) (1) of 4-NP and 2 µg g(-) (1) week(-) (1) of E2, and their blood plasma was obtained for biochemical analysis on days 0, 7 and 14.
* Induction of vitellogenin synthesis in immature male yellowfin seabream (Acanthopagrus latus) exposed to 4-nonylphenol and 17β-estradiol.
- In the present study, the effects of xenoestrogen 4-nonylphenol (4-NP) and 17β-estradiol (E2) on the synthesis of vitellogenin (VTG) in immature male yellowfin seabream (Acanthoparus latus) were assessed to determine the potential use of this species as a biological model for studying endocrine disrupters in the Musa estuary in southern seawaters of Iran. A total number of 104 fish were injected by 10, 50, 100, 150 and 200 µg g(-) (1) week(-) (1) of 4-NP and 2 µg g(-) (1) week(-) (1) of E2, and their blood plasma was obtained for biochemical analysis on days 0, 7 and 14. The hepatosomatic index (HSI) of each fish was also recorded at each sampling time. The results showed that 4-NP significantly induced VTG synthesis in A. latus, which was detected by gel electrophoresis as two major protein bands (∼210 and 191 KDa). The induction of VTG was also determined indirectly by measuring the alkali-labile phosphate, total plasma calcium and protein. All of these VTG indicators significantly increased in the plasma of 4-NP- and E2-treated fish. Meanwhile, a significant dose-dependent increase was observed in HSI, indicating the activation of hepatic VTG production in 4-NP- and E2-injected fish. Furthermore, the plasma alanine aminotransferase and aspartate aminotransferase concentrations significantly increased in 4-NP-treated fish, presumably reflecting a situation of hepatic tissue damage due to 4-NP toxicity. Based on the results, it is suggested that A. latus could be used successfully as a model species for future studies of endocrine disrupting contaminants in the Musa estuary.
=>1.(車が)全壊する, 全損する, 2.全体の, 全ての, 総計の, 総体の, 全くの, 完全な, 総力の, 3.総額, 総計,
全体の, (車が)全壊する, 合計(する), なる
Overview of noun total
The noun total has 2 senses (first 2 from tagged texts)
1. (13) sum, total, totality, aggregate -- (the whole amount)
2. (6) sum, amount, total -- (a quantity obtained by the addition of a group of numbers)
Overview of verb total
The verb total has 3 senses (first 2 from tagged texts)
1. (16) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to
$2,000"; "The bill came to $2,000")
2. (2) total, tot, tot up, sum, sum up, summate, tote up, add, add together, tally, add up --
(determine the sum of; "Add all the people in this town to those of the neighboring town")
3. total -- (damage beyond the point of repair; "My son totaled our new car"; "the rock star totals
his guitar at every concert")
Overview of adj total
The adj total has 2 senses (first 2 from tagged texts)
1. (31) entire, full, total -- (constituting the full quantity or extent; complete; "an entire town
devastated by an earthquake"; "gave full attention"; "a total failure")
2. (2) full, total -- (complete in extent or degree and in every particular; "a full game"; "a total
eclipse"; "a total disaster")
--- WordNet end ---