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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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296134 occurrences (No.80 in the rank) during 5 years in the PubMed. [no cache] 500 found
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296134 occurrences (No.80 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 311) In multivariate logistic regression analyses, the use of warfarin was associated with increased odds of aortic (OR 2.58, p<0.001) and iliac calcifications (OR 2.86, p<0.001); identified confounders were age, atrial fibrillation, angina, PPI use and total BGP. |
| PMID:23927679 DOI:10.1111/hepr.12218 |
| 2015 Current vascular pharmacology |
| * Prevalence of vertebral fractures, vascular calcifications, and mortality in warfarin treated hemodialysis patients. |
| - Warfarin inhibits vitamin-K dependent proteins involved in bone mineralization and the prevention of vascular calcification (bone Gla protein BGP, matrix Gla protein MGP). In this multicenter, cross-sectional study with 3-year follow-up, data from 387 patients on hemodialysis for ≥1 year at 18 dialysis units were analyzed. Patients on warfarin treatment for > 1 year (11.9% of the population) were compared with the remaining cohort for vertebral fractures, vascular calcifications and mortality. Vertebral fractures and vascular calcifications were sought in L-L vertebral X-rays (D5 to L4). Compared with controls, warfarin-treated male patients had more vertebral fractures (77.8 vs. 57.7%, p<0.04), but not females (42.1% vs. 48.4%, p=0.6); total BGP was significantly reduced (82.35 vs. 202 µg/L, p<0.0001), with lower levels in treated men (69.5 vs. women 117.0 µg/L, p=0.03). In multivariate logistic regression analyses, the use of warfarin was associated with increased odds of aortic (OR 2.58, p<0.001) and iliac calcifications (OR 2.86, p<0.001); identified confounders were age, atrial fibrillation, angina, PPI use and total BGP. Seventy-seven patients died during a 2.7±0.5 year follow-up. In univariate Cox regression analysis, patients on warfarin had a higher risk of all-cause mortality (HR 2.42, 95% CI 1.42-4.16, p=0.001) when compared with those untreated and data adjustment for confounders attenuated but confirmed the significant warfarin-mortality link (HR: 1.97, 95% CI: 1.02-3.84, P=0.046). In hemodialysis patients, additional studies are warranted to verify the risk/benefit ratio of warfarin, which appears to be associated with significant morbidity and increased mortality. |
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(27)2 BGP |
(40)2 organic |
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(15)3 annual |
(28)2 DNA, |
(41)2 oxidant |
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(42)2 pleural |
| (4)7 antioxidant |
(17)3 knee |
(30)2 arch |
(43)2 protein, |
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(31)2 biomass |
(44)2 repetitions |
| (6)5 body |
(19)3 optical |
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(33)2 daily |
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(21)3 parenteral |
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(22)3 polyphenols |
(35)2 exercise |
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(23)3 population |
(36)2 genome |
(49)2 tumor |
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(24)3 sample |
(37)2 health-care |
(50)2 volume |
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(25)3 suspended |
(38)2 islet |
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