* Effect of fibroblast-seeded artificial dermis on wound healing.
- In covering wounds, efforts should include use of the safest and least invasive methods with a goal of achieving optimal functional and cosmetic outcome. The recent development of advanced technology in wound healing has triggered the use of cells and/or biological dermis to improve wound healing conditions. The purpose of the study was to evaluate the effects of fibroblast-seeded artificial dermis on wound healing efficacy.Ten nude mice were used in this study. Four full-thickness 6-mm punch wounds were created on the dorsal surface of each mouse (total, 40 wounds). The wounds were randomly assigned to one of the following 4 treatments: topical application of Dulbecco phosphate-buffered saline (control), human fibroblasts (FB), artificial dermis (AD), and human fibroblast-seeded artificial dermis (AD with FB). On the 14th day after treatment, wound healing rate and wound contraction, which are the 2 main factors determining wound healing efficacy, were evaluated using a stereoimage optical topometer system, histomorphological analysis, and immunohistochemistry.The results of the stereoimage optical topometer system demonstrated that the FB group did not have significant influence on wound healing rate and wound contraction. The AD group showed reduced wound contraction, but wound healing was delayed. The AD with FB group showed decreased wound contraction without significantly delayed wound healing. Histomorphological analysis exhibited that more normal skin structure was regenerated in the AD with FB group. Immunohistochemistry demonstrated that the AD group and the AD with FB group produced less α-smooth muscle actin than the control group, but this was not shown in the FB group.Fibroblast-seeded artificial dermis may minimize wound contraction without significantly delaying wound healing in the treatment of skin and soft tissue defects.
=>1.(車が)全壊する, 全損する, 2.全体の, 全ての, 総計の, 総体の, 全くの, 完全な, 総力の, 3.総額, 総計,
全体の, (車が)全壊する, 合計(する), なる
Overview of noun total
The noun total has 2 senses (first 2 from tagged texts)
1. (13) sum, total, totality, aggregate -- (the whole amount)
2. (6) sum, amount, total -- (a quantity obtained by the addition of a group of numbers)
Overview of verb total
The verb total has 3 senses (first 2 from tagged texts)
1. (16) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to
$2,000"; "The bill came to $2,000")
2. (2) total, tot, tot up, sum, sum up, summate, tote up, add, add together, tally, add up --
(determine the sum of; "Add all the people in this town to those of the neighboring town")
3. total -- (damage beyond the point of repair; "My son totaled our new car"; "the rock star totals
his guitar at every concert")
Overview of adj total
The adj total has 2 senses (first 2 from tagged texts)
1. (31) entire, full, total -- (constituting the full quantity or extent; complete; "an entire town
devastated by an earthquake"; "gave full attention"; "a total failure")
2. (2) full, total -- (complete in extent or degree and in every particular; "a full game"; "a total
eclipse"; "a total disaster")
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