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677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found

30) Commercially available engineered alternative tissues have become a valuable adjunct to the treatment of burn injuries.

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PMID:23834497 DOI:10.1111/iwj.12126

2015 International wound journal

* Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue.

- Burn wound care today has a primary objective of temporary or permanent wound closure. Commercially available engineered alternative tissues have become a valuable adjunct to the treatment of burn injuries. Their constituents can be biological, alloplastic or a combination of both. Here the authors describe the aspects of the development of a siloxane epidermis for a collagen-glycosaminoglycan and for nylon-based artificial skin replacement products. A method to fabricate an ultra-thin epidermal equivalent is described. Pores, to allow the escape of wound exudate, were punched and a tri-filament nylon mesh or collagen scaffold was imbedded and silicone polymerisation followed at 120°C for 5 minutes. The ultra-structure of these bilaminates was assessed through scanning electron microscopy. An ultra-thin biomedical grade siloxane film was reliably created through precision coating on a pre-treated polyethylene terephthalate carrier.

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