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677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [cache]

345) We observe that Peto odds ratio estimators in a multi-arm study are inconsistent if the observed event probabilities are different or the sample sizes of treatment groups are unbalanced.

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PMID:34133079 DOI:10.1002/jrsm.1503

2021 Research synthesis methods

* Inconsistent results for Peto odds ratios in multi-arm studies, network meta-analysis and indirect comparisons.

- The Peto odds ratio is a well-known effect measure in meta-analysis of binary outcomes. For pairwise comparisons, the Peto odds ratio estimator can be severely biased in the situation of unbalanced sample sizes in the two treatment groups or large treatment effects. In this publication, we evaluate Peto odds ratio estimators in the setting of multi-arm studies and in network meta-analysis using illustrative examples. We observe that Peto odds ratio estimators in a multi-arm study are inconsistent if the observed event probabilities are different or the sample sizes of treatment groups are unbalanced. The same problem emerges in network meta-analysis including only two-arm studies and translates to indirect comparisons of pairwise meta-analyses. We conclude that the Peto odds ratio should not be used as effect measure in network meta-analysis or indirect comparisons of pairwise meta-analyses.

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(1)68 of	(13)7 planning	(25)3 outcome	(37)2 efficacy
(2)50 null	(14)6 to	(26)3 protocols	(38)2 goals
(3)29 and	(15)4 approaches	(27)3 that	(39)2 group
(4)23 for	(16)4 methods	(28)2 a	(40)2 groups
(5)22 with	(17)4 option	(29)2 as	(41)2 may
(6)15 options	(18)4 options,	(30)2 at	(42)2 ranks
(7)13 in	(19)4 ranking	(31)2 being	(43)2 reduced
(8)9 effect	(20)4 regimens	(32)2 compared	(44)2 resistance
(9)9 effects	(21)4 strategies	(33)2 decisions,	(45)2 screening,
(10)8 is	(22)3 adherence	(34)2 development	(46)2 through
(11)8 on	(23)3 approach	(35)2 did	(47)2 were
(12)7 outcomes	(24)3 or	(36)2 dose

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---