* The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma.
- Increasing evidence indicates that deregulation of RING-finger ubiquitin-protein ligases (E3s) involves in the development of hepatocellular carcinoma (HCC). These RING-finger E3s serve as oncoproteins or tumor suppressors in HCC under specific conditions. In this review, we summarize current knowledge about abnormal RING-finger E3s and their clinical significance in the development of HCC, and discuss parts of critical substrates for these RING-finger E3s in detail. Furthermore, in light of success of Bortezomib in treating hematological malignancies, we describe the preclinical and clinical studies of therapeutic approaches targeting aberrant RING-finger E3s in HCC.
=>膨らみ, 出っ張り, 腫瘍
Overview of noun tumor
The noun tumor has 1 sense (first 1 from tagged texts)
1. (18) tumor, tumour, neoplasm -- (an abnormal new mass of tissue that serves no purpose)
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