ELIZA

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321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [cache]

226) Specifically, we study the mechanical properties and structural stability of BMV under controlled molecular crowding conditions.

--- ABSTRACT ---

PMID:33577322 DOI:10.1021/acs.jpcb.0c10947

2021 The journal of physical chemistry. B

* Virus Mechanics under Molecular Crowding.

- Viruses avoid exposure of the viral genome to harmful agents with the help of a protective protein shell known as the capsid. A secondary effect of this protective barrier is that macromolecules that may be in high concentration on the outside cannot freely diffuse across it. Therefore, inside the cell and possibly even outside, the intact virus is generally under a state of osmotic stress. Viruses deal with this type of stress in various ways. In some cases, they might harness it for infection. However, the magnitude and influence of osmotic stress on virus physical properties remains virtually unexplored for single-stranded RNA viruses-the most abundant class of viruses. Here, we report on how a model system for the positive-sense RNA icosahedral viruses, brome mosaic virus (BMV), responds to osmotic pressure. Specifically, we study the mechanical properties and structural stability of BMV under controlled molecular crowding conditions. We show that BMV is mechanically reinforced under a small external osmotic pressure but starts to yield after a threshold pressure is reached. We explain this mechanochemical behavior as an effect of the molecular crowding on the entropy of the "breathing" fluctuation modes of the virus shell. The experimental results are consistent with the viral RNA imposing a small negative internal osmotic pressure that prestresses the capsid. Our findings add a new line of inquiry to be considered when addressing the mechanisms of viral disassembly inside the crowded environment of the cell.

--- ABSTRACT END ---

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(1)136 the	(18)4 oxidative	(35)2 Nanotechnology	(52)2 medical
(2)13 different	(19)4 physiological	(36)2 RNA	(53)2 montelukast
(3)10 a	(20)4 six	(37)2 SD,	(54)2 nanoconfinement
(4)8 null	(21)4 study	(38)2 anaerobic	(55)2 nutritional
(5)7 investigation	(22)3 acidic	(39)2 anesthesia	(56)2 other
(6)7 of	(23)3 and	(40)2 certain	(57)2 our
(7)6 in	(24)3 basal	(41)2 common	(58)2 real
(8)6 normal	(25)3 conditions	(42)2 curve	(59)2 real-world
(9)6 these	(26)3 control	(43)2 each	(60)2 this
(10)5 an	(27)3 development	(44)2 endoscopic	(61)2 three
(11)5 both	(28)3 high	(45)2 ex	(62)2 treatment
(12)5 which	(29)3 inverted	(46)2 fasted	(63)2 two
(13)4 assessment	(30)3 some	(47)2 five	(64)2 typical
(14)4 clinical	(31)3 various	(48)2 four	(65)2 water-deficit
(15)4 controlled	(32)3 water	(49)2 hypoxia
(16)4 general	(33)2 18	(50)2 intense
(17)4 hypoxic	(34)2 808	(51)2 low

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---