ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for under out of >500 occurrences
321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache] 500 found
31) Stabilisation of HIF1α protein in cumulus cells exposed to low oxygen was confirmed by western blot and HIF-mediated transcriptional activity was demonstrated using a transgenic mouse expressing green fluorescent protein under the control of a promoter containing hypoxia response elements.
--- ABSTRACT ---
PMID:24388334 DOI:10.1071/RD13249
2015 Reproduction, fertility, and development
* Oxygen-regulated gene expression in murine cumulus cells.
- Oxygen is an important component of the environment of the cumulus-oocyte complex (COC), both in vivo within the ovarian follicle and during in vitro oocyte maturation (IVM). Cumulus cells have a key role in supporting oocyte development, and cumulus cell function and gene expression are known to be altered when the environment of the COC is perturbed. Oxygen-regulated gene expression is mediated through the actions of the transcription factors, the hypoxia-inducible factors (HIFs). In the present study, the effect of oxygen on cumulus cell gene expression was examined following in vitro maturation of the murine COC at 2%, 5% or 20% oxygen. Increased expression of HIF-responsive genes, including glucose transporter-1, lactate dehydrogenase A and BCL2/adenovirus E1B interacting protein 3, was observed in cumulus cells matured at 2% or 5%, compared with 20% oxygen. Stabilisation of HIF1α protein in cumulus cells exposed to low oxygen was confirmed by western blot and HIF-mediated transcriptional activity was demonstrated using a transgenic mouse expressing green fluorescent protein under the control of a promoter containing hypoxia response elements. These results indicate that oxygen concentration influences cumulus cell gene expression and support a role for HIF1α in mediating the cumulus cell response to varying oxygen.
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(1)95 the (18)4 these (35)2 axial (52)2 of
(2)13 different (19)3 high (36)2 censoring (53)2 optimal
(3)12 a (20)3 investigation (37)2 clinical (54)2 physiological
(4)9 general (21)3 light (38)2 consideration (55)2 pulsatile
(5)8 both (22)3 local (39)2 controlled (56)2 scanning
(6)8 which (23)3 mechanical (40)2 current (57)2 serum-free
(7)7 various (24)2 *null* (41)2 evaluation (58)2 several
(8)6 conditions (25)2 12 (42)2 ex (59)2 simulated
(9)6 curve (26)2 15 (43)2 extreme (60)2 specific
(10)6 static (27)2 2 (44)2 four (61)2 steady-state
(11)5 and (28)2 CA (45)2 hypertensive (62)2 therapy
(12)4 5 (29)2 CT (46)2 hypoxia (63)2 this
(13)4 certain (30)2 H2O2-induced (47)2 hypoxic (64)2 time
(14)4 control (31)2 UV (48)2 inflammatory (65)2 treatment
(15)4 either (32)2 acute (49)2 laser (66)2 ultrasound
(16)4 in (33)2 additive (50)2 lateral (67)2 vertical
(17)4 normal (34)2 adverse (51)2 mortality (68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---