kwic
while
while
right
off
ON
162
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for while out of >500 occurrences
341393 occurrences (No.55 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to while]
341393 occurrences (No.55 in the rank) during 5 years in the PubMed. [cache]
| 162) Research and clinical application of nanoparticles like liposomes for drug delivery requires targeting them to specific anatomic regions or cell types, while avoiding off-target effects or clearance by the liver, kidney, or the immune system. |
| PMID:33928585 DOI:10.1007/978-1-0716-1298-9_20 |
| 2021 Methods in molecular biology (Clifton, N.J.) |
| * siRNA Therapeutics for Protein Misfolding Diseases of the Central Nervous System. |
| - Nanoparticles have been used to deliver siRNA to tissues and cells to silence specific genes in diverse organisms. Research and clinical application of nanoparticles like liposomes for drug delivery requires targeting them to specific anatomic regions or cell types, while avoiding off-target effects or clearance by the liver, kidney, or the immune system. Delivery to the central nervous system (CNS) presents additional challenges to cross the blood-brain barrier (BBB) to specific cell types like neurons, astrocytes, or glia. Here, we describe the generation of three different liposomal siRNA delivery vehicles to the CNS using the thin film hydration method. Utilizing cationic or anionic liposomes protects the siRNA from serum nucleases and proteases en route. To deliver the siRNA specifically to the CNS, the liposomes are complexed to a peptide that acts as a neuronal address by binding to nicotinic acetylcholine receptors (nAchRs). When injected intravenously or instilled intranasally, these liposome-siRNA-peptide complexes (LSPCs) or peptide addressed liposome-encapsulated therapeutic siRNA (PALETS) resist serum degradation, effectively cross the BBB, and deliver siRNA to AchR-expressing cells to suppress protein expression in the CNS. |
[
right
kwic]
(1)64  the |
(14)4 others |
(27)2 aged |
(40)2 minimizing |
| (2)11 also |
(15)4 several |
(28)2 asthma |
(41)2 on |
| (3)10 there |
(16)4 simultaneously |
(29)2 being |
(42)2 preserving |
| (4)9 a |
(17)4 social |
(30)2 both |
(43)2 previous |
| (5)7 in |
(18)3 avoiding |
(31)2 clinical |
(44)2 reducing |
| (6)7 most |
(19)3 many |
(32)2 commercial |
(45)2 screening |
| (7)7 some |
(20)3 more |
(33)2 controlling |
(46)2 showing |
| (8)7 these |
(21)3 none |
(34)2 identifying |
(47)2 syphilis |
| (9)6 it |
(22)3 promoting |
(35)2 improving |
(48)2 three |
| (10)4 all |
(23)3 this |
(36)2 intrusive |
(49)2 two |
| (11)4 for |
(24)3 using |
(37)2 its |
(50)2 walking |
| (12)4 maintaining |
(25)2 N |
(38)2 living |
|
| (13)4 no |
(26)2 accounting |
(39)2 longer |
add keyword
--- WordNet output for while ---