ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for while out of >500 occurrences
341393 occurrences (No.55 in the rank) during 5 years in the PubMed. [no cache] 500 found
31) Many of these inhibitors have shown promise, while the effects of others are tempered by the mechanisms through which HNSCC can evade therapy.
--- ABSTRACT ---
PMID:24219320 DOI:10.1111/odi.12206
2015 Oral diseases
* The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.
- Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations in major components of the PI3K/Akt/mTOR pathway are consistently observed throughout the majority of HNSCC cases. These alterations include genetic aberrations, such as mutations or DNA copy number variations, and dysregulation of mRNA or protein expression. In normal physiology, the PI3K/Akt/mTOR axis regulates cell survival, growth, and metabolism. However, alterations in this pathway lead to the malignant phenotype which characterizes HNSCC, among many other cancers. For this reason, both pharmaceutical companies and academic institutions are actively developing and investigating inhibitors of PI3K, Akt, and mTOR in preclinical and clinical studies of HNSCC. Many of these inhibitors have shown promise, while the effects of others are tempered by the mechanisms through which HNSCC can evade therapy. As such, current research aimed at elucidating the interactions between PI3K/Akt/mTOR and other important signaling pathways which may drive resistance in HNSCC, such as p53, NF-κB, and MAPK, has become a prominent focus toward better understanding how to most effectively treat HNSCC.
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[frequency of next (right) word to while]
(1)79 the (16)3 it (31)2 environmental (46)2 promoting
(2)14 in (17)3 its (32)2 focusing (47)2 providing
(3)13 no (18)3 most (33)2 for (48)2 receiving
(4)11 a (19)3 others (34)2 further (49)2 serum
(5)6 this (20)3 that (35)2 harvesting (50)2 she
(6)4 at (21)3 there (36)2 increasing (51)2 significant
(7)4 maintaining (22)3 these (37)2 minimising (52)2 similar
(8)4 one (23)3 those (38)2 much (53)2 slightly
(9)4 performing (24)3 women (39)2 negative (54)2 some
(10)4 reducing (25)2 Asians (40)2 numerous (55)2 still
(11)4 retaining (26)2 accounting (41)2 on (56)2 subcutaneous
(12)4 simultaneously (27)2 also (42)2 other (57)2 their
(13)4 they (28)2 controlling (43)2 participants
(14)4 using (29)2 digging/gardening, (44)2 preserving
(15)3 20% (30)2 downregulation (45)2 previous

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--- WordNet output for while --- =>時間と労働, その間に, 時間, する間に, なのに, そのうえ, をのんびりと過す Overview of noun while The noun while has 1 sense (first 1 from tagged texts) 1. (23) while, piece, spell, patch -- (a period of indeterminate length (usually short) marked by some action or condition; "he was here for a little while"; "I need to rest for a piece"; "a spell of good weather"; "a patch of bad weather") --- WordNet end ---